Abstract
The lipid-lowering activity of a series of novel
N
-(benzoylphenyl)-5-fluoro-1
H
-indole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1:
N
-(2-benzoylphenyl)-5-fluoro-1
H
-indole-2-carboxamide (
1
), C2:
N
-(3-benzoylphenyl)-5-fluoro-1
H
-indole-2-carboxamide (
2
), C3:
N
-(4-benzoylphenyl)-5-fluoro-1
H
-indole-2-carboxamide (
3
)]-treated and bezafibrate (BF)-treated. At a dose of 15 mg/Kg body weight, compounds
2, 3
and BF significantly reduced elevated plasma triglycerodes levels after 12 h. Moreover, high density lipoprotein-cholesterol levels were significantly increased in all treated groups after 12 h compared to the hyperlipidemic control group, except for
C1
which was inactive. In sum, it may be stated that the results of the present study demonstrated new properties of some
N
-(benzoylphenyl)-5-fluoro-
1H
-indole-2-carboxamide derivatives as potent lipid lowering agents and these beneficial activities may contribute to their cardioprotective and antiatherosclerotic role.