Abstract
A new series of 5,5'-(2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-diyl)bis[4-(ethylideneamino)-4
H
-[1,2,4]-triazole-3-thiol) was synthesized via keto-imine condensation. The structural elucidation of the products was investigated by spectral and elemental techniques. Also, the newly synthesized compounds were evaluated for their in vitro anti-tubercular activity, the sensitive and resistant Mycobacterium tuberculosis. Among sixteen tested compounds, compound (
V
) is equipotent to the standard drug isoniazid against sensitive Mycobacterium tuberculosis, while compounds (
IXb
), (
VIId
), and (
IIIf
) have promising activity.