Abstract
Sixteen novel oxazolidinone analogs containing substituted thiazole/fused-bicyclic (imidazo [1, 2-b] pyridazine/imidazo [2, 1-b] thiazole) groups were designed and synthesized. A new method for the preparation of the key intermediate compound
11 was proposed. The structures of the target compounds were confirmed by
1H NMR, IR and MS, and their
in vitro antibacterial activities against
staphylococcus aureus were evaluated. Among them, compound
16a displays a promising antibacterial activity comparable to that of linezolid.