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Synthesis and Antimalarial Bioassay of Quinine - Peptide Conjugates
Journal article   Peer reviewed

Synthesis and Antimalarial Bioassay of Quinine - Peptide Conjugates

Siva S. Panda, Mohamed A. Ibrahim, Hasan Kucukbay, Marvin J. Meyers, Francis M. Sverdrup, Said A. El-Feky and Alan R. Katritzky
Chemical biology & drug design, Vol.82(4), pp.361-366
01/10/2013
DOI: https://doi.org/10.1111/cbdd.12134
PMID: 23497252

Abstract

Biochemistry & Molecular Biology Chemistry, Medicinal Life Sciences & Biomedicine Pharmacology & Pharmacy Science & Technology
Amino acid and peptide conjugates of quinine were synthesized using microwave irradiation in 52-95% yields using benzotriazole methodology. The majority of these conjugates retain in vitro antimalarial activity with IC50 values below 100nm, similar to quinine.

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