Abstract
New 2,5-disubstituted 1,3,4-oxadiazole derivatives bearing C-furyl glycoside moieties and their sugar hydrazone as well as their per-O-acetyl derivatives were synthesized starting from ethyl 2-[5-(3,4-dihydroxytetrahydrofuran-2-yl)-2-methylfuran-3-yl]-2-oxoacetate. Heterocyclization of the sugar hydrazones using acetic anhydride afforded the corresponding oxadiazoline acyclic C-nucleosides. The antimicrobial activity evaluation showed that many of the synthesized compounds revealed moderate to high antimicrobial activity.