Synthesis and Antimicrobial Evaluation. of Some New Pyrazole, Fused Pyrazolo[1,5-a]-pyrimidine and Pyrazolo[1,5-d]pyrimido[4,5-d][1,2,3]triazine Derivatives

Elham S. Darwish; Fivian F. Mahmoud; Farag M. A. Altalbawy

Back

Journal article

Synthesis and Antimicrobial Evaluation. of Some New Pyrazole, Fused Pyrazolo[1,5-a]-pyrimidine and Pyrazolo[1,5-d]pyrimido[4,5-d][1,2,3]triazine Derivatives

Elham S. Darwish, Fivian F. Mahmoud and Farag M. A. Altalbawy

Asian journal of chemistry, Vol.24(7), pp.2997-3002

01/07/2012

Abstract

Chemistry

Chemistry, Multidisciplinary

Physical Sciences

Science & Technology

A variety of 3-arylazo-5-amino and 7-amino pyrazolo[1,5-a] pyrimidines were obtained via reacting 1 with cinnamonitriles and methoxymethylene malononitrile. Diazotized 1 coupled with active methylene reagents to yield pyrazolo[5,1-c][1,2,4]triazines. The products were screened for their antifungal and antibacterial activity properties and showed promising results. The mechanism of the studied reactions is discussed. The structures of the compounds prepared were elucidated on the basis of their elemental analyses, spectral data and alternate synthesis.

Metrics

1 Record Views

Details

Title: Synthesis and Antimicrobial Evaluation. of Some New Pyrazole, Fused Pyrazolo[1,5-a]-pyrimidine and Pyrazolo[1,5-d]pyrimido[4,5-d][1,2,3]triazine Derivatives
Creators - without role: Elham S. Darwish - Cairo University
Fivian F. Mahmoud - Al Azhar Univ, Fac Sci, Dept Chem, Cairo, Egypt
Farag M. A. Altalbawy - Cairo University
Publication Details: Asian journal of chemistry, Vol.24(7), pp.2997-3002
Publisher: Asian Journal Of Chemistry
Number of pages: 6
Identifiers: 9933906708331
Academic Unit: University of Tabuk
Language: English
Resource Type: Journal article