Abstract
A series of twelve pyrralothiazoles was synthesized using [3+2]- cycloaddition reactions. The synthesized compounds were screened for their antimycobacterial activity against M. tuberculosis H(37)Rv and INH resistant M. tuberculosis strains using agar dilution method, four of them showed good activity with MIC of less than 1 mu M. Compound (4d) was found to be the most active with MIC of 0.231 mu M and 4.372 mu M respectively.