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Synthesis and Antioxidant, Anti-Inflammatory, and Analgesic Activity of Novel Polycyclic Pyrimido[4,5-b]quinolines
Journal article   Peer reviewed

Synthesis and Antioxidant, Anti-Inflammatory, and Analgesic Activity of Novel Polycyclic Pyrimido[4,5-b]quinolines

A. B. A. El-Gazzar, H. N. Hafez, A. A. Abu-Hashem and A. S. Aly
Phosphorus, sulfur, and silicon and the related elements, Vol.184(2), pp.379-405
03/02/2009
DOI: https://doi.org/10.1080/10426500802167027

Abstract

Chemistry Chemistry, Inorganic & Nuclear Chemistry, Organic Physical Sciences Science & Technology
The behavior of the 2-methylthio-pyrimido[4,5-b]quinolin-4-one towards differently substituted amines is reported. Also, the reactivity of 3-aminothiazolo[3',2' :1,2]-pyrimido[4,5-b]quinoline-2-carbonitrile towards formic acid, urea, thiourea, formamide, and carbon disulfide is discussed. Some of the synthesized derivatives possess biological activities as anti-inflammatory and analgesic agents. Some of these selective biologically active compounds were screened for antioxidant properties.

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