Abstract
A series of some new heterocyclic scaffolds containing thiazole moiety was synthesized through the reaction of 2-chloroacetamidothiazole (1) with various types of nucleophiles, namely ethyl thioglycolate, 2-mercaptobenzothiazole, 2-mercaptobenzoxazole, malononitrile, salicylaldehyde, ammonium thiocyanate, and 3-cyano-4,6-dimethyl-5-phenylazopyridin-2-one. The antioxidant property of the newly prepared thiazole scaffolds has been evaluated by 2,2-diphenyl-1-picrylhydrazyl radical scavenging technique. The maximum antioxidant power was observed for compounds 4a and 11b that contain two thiazole rings.
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