Abstract
A convenient method for the synthesis of new organoselenium compounds was described from simple 2methoxy- 4-selenocyanato-aniline (1) and its corresponding diselenide 2. The chemical reactivity of N, N'-(diselanediylbis(2methoxy- 4,1-phenylene)) bis-(2-chloro-acetamide) (3) was investigated towards several type of carbon and sulfur nucleophiles to furnish various heterocyclic diselenide derivatives. Moreover, the new synthesized compounds were evaluated for their antitumor activity and were found to be more cytotoxic compared to their corresponding analogues without selenium.