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Synthesis and Antiviral Bioassay of New Diphenyl Ether-based Compounds
Journal article   Peer reviewed

Synthesis and Antiviral Bioassay of New Diphenyl Ether-based Compounds

Tarek S Ibrahim, Amany M M Al-Mahmoudy, Mohamed Elagawany, Mohamed A Ibrahim and Siva S Panda
Chemical biology & drug design, Vol.88(4), pp.511-518
10/2016
DOI: https://doi.org/10.1111/cbdd.12775
PMID: 27096302

Abstract

Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological Assay Biphenyl Compounds - chemical synthesis Biphenyl Compounds - chemistry Biphenyl Compounds - pharmacology Cells, Cultured Drug Evaluation, Preclinical Ether - chemical synthesis Ether - chemistry Ether - pharmacology Humans Models, Molecular Molecular Structure Pyrazoles - chemistry Pyrazoles - pharmacology Pyridines - chemistry Pyridines - pharmacology Viruses - drug effects
A set of diphenyl ether derivatives bearing different heterocycles were synthesized from 4-phenoxybenzohydrazide 1 in good yield. Synthesized compounds were screened against a broad panel of viruses in different cell cultures and some of the synthesized compounds showed promising antiviral properties.

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