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Synthesis and Biodistribution of Tc-99m-PyDA as a Potential Marker for Tumor Hypoxia Imaging
Journal article   Peer reviewed

Synthesis and Biodistribution of Tc-99m-PyDA as a Potential Marker for Tumor Hypoxia Imaging

T. M. Sakr, B. M. Essaa, F. A. El-Essawy and A. A. El-Mohty
Radiochemistry (New York, N.Y.), Vol.56(1), pp.76-80
01/01/2014
DOI: https://doi.org/10.1134/S1066362214010159

Abstract

Chemistry Chemistry, Analytical Chemistry, Inorganic & Nuclear Physical Sciences Science & Technology
The Tc-99m-pyrimidine-4,5-diamine (Tc-99m-PyDA) complex was prepared. The yield under the optimum conditions (5 mg of PyDA, pH 8, 25 mu g of SnCl2 center dot 2H(2)O) was 96 +/- 3%. The complex is stable in vitro for 24 h. The complex was tested on mice as potential marker for tumor hypoxia imaging. The complex showed high tumor hypoxia uptake with the target/nontarget (T/NT) ratio as high as similar to 3.

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