Abstract
Nitrogen containing synthetically and biologically important heterocyclic ring system namely pyrimidine possess both biological and pharmacological activities and defend as aromatic six heterocyclic with 1 and 3 nitrogen atom in ring. Preparation of pyrimidine via different methods offer its importance in fields of medicinal chemistry and Chemistry. Pyrimidines and their derivatives act as anti-inflammatory, anti-malaria, anti-tumor, cardiovascular agents, anti-neoplastic, anti-tubercular, anti-HIV, diuretic, anti-viral, anti-microbial, analgesic. This review give light up on biological and pharmacological activities of pyrimidine nucleus.