Synthesis and Characterization of 3-Methylene Isoindolinones by Two Synthetic Routes

Hamida Jelali; Lamjed Mansour; Jameel Al-Tamimi; Eric Deniau; Mathieu Sauthier; Naceur Hamdi

doi:10.1080/10406638.2021.1971269

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Synthesis and Characterization of 3-Methylene Isoindolinones by Two Synthetic Routes

Journal article

Peer reviewed

Synthesis and Characterization of 3-Methylene Isoindolinones by Two Synthetic Routes

Hamida Jelali, Lamjed Mansour, Jameel Al-Tamimi, Eric Deniau, Mathieu Sauthier and Naceur Hamdi

Polycyclic aromatic compounds, Vol.ahead-of-print(ahead-of-print), pp.1-13

22/08/2021

DOI: https://doi.org/10.1080/10406638.2021.1971269

Abstract

3-methyleneisoindolinones

methylmagnesuim bromide

Microwave-assisted synthesis

The aim of this study was a detailed examination of the synthesis of 3-methyleneisoindolinones comprising various functional groups. Methylmagnesuim bromide and PTSA was employed for the synthesis of these compounds. A wide range of 3-methyleneisoindolinones were afforded in good to excellent yields. On the other hand, 3-methyleneisoindolinones was also obtained by an efficient microwave method. The frame work of these derivatives was constructed from 2- acetylbenzoic acid and various primary amines via two-component reaction. The obtained compounds were characterized by 1 H NMR, 13 C-NMR and IR and elemental analysis.

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Title: Synthesis and Characterization of 3-Methylene Isoindolinones by Two Synthetic Routes
Creators - without role: Hamida Jelali - University of Carthage
Lamjed Mansour - King Saud University
Jameel Al-Tamimi - King Saud University
Eric Deniau - Artois University
Mathieu Sauthier - Artois University
Naceur Hamdi - Qassim University
Publication Details: Polycyclic aromatic compounds, Vol.ahead-of-print(ahead-of-print), pp.1-13
Publisher: Taylor & Francis
Identifiers: 9929203408331
Academic Unit: Qassim University; King Saud University
Language: English
Resource Type: Journal article