Abstract
Metformin considered as a drug that widely used in the treatment of diabetes type-2 patients, and it is recommended for management of hyperglycaemia as the first-line agent. This research included the preparation of new derivatives of metformin 1-8 which contain in their composition both cyclic imide and metformin components with expected anti-diabetic effects, via two methods, the first involved reacting metformin with different anhydrides (maleic, succinic, citraconic, phthalic, pyridinic, pyromillitic) in the presence of glacial acetic acid as a solvent and dehydrating agent. The second involved smelting of metformin with equimolar amount of anhydrides (1,8-naphthalicanhydride and 1,4,6,8-naphthalicdianhydride). The compositions of the synthesized compounds 1-8 were confirmed using FT-IR spectroscopy, (HNMR)-H-1 spectroscopy and elemental analysis (C, H, N, O), and the practical results were in agreement with the expected results.