Abstract
New coumarin derivatives, namely (2-(4-methyl-2-oxo-
2H
-chromen-7-yloxy)-
N
-(4-oxo-2-phenylthiazolidin-3-yl)acetamide,
N
-(2-(3-methoxyphenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-
2H
-chromen-7-yloxy)acetamide, 2-(4-methyl-2-oxo-
2H
-chromen-7-yloxy)-
N
-(4-oxo-2-(2,3,4trimethoxyphenyl)thiazolidin-3-yl)acetamide and
N
-(2-(4-bromophenyl)-4-oxothiazolidin-3-yl)-2-(4-methyl-2-oxo-
2H
-chromen-7-yloxy)acetamide) were synthesized starting from 4-methyl-7-hydroxycoumarin. The structures of the obtained compounds were confirmed by analytical IR and NMR spectra to elucidate the different positions of protons and carbons and as well as theoretical studies (DFT/B3LYP). The new compounds were screened for antibacterial activity. Most of them are more active against
E. coli S. aureus
and
B. subtilis
than standard references.