Abstract
New 1,4-bithiazolyl-5-oxopyrrole derivatives have been synthesized via a multicomponent reaction (MCR) and their structures characterized.
N
1
-Phenyl- and
N
1
-amino-substituted 1,2,4-triazole derivatives linked with bithiazolyl-5-oxopyrrole system also have been synthesized. Glycosylation of the latter
s
-triazole compounds by acetylated glycosyl halides has led to the corresponding thioglycoside derivatives. Cytotoxic activity data of the synthesized compounds against colon (HCT-116) and breast (MCF-7) human cancer sells determined by the MTT assay indicate two 1,2,4-triazole thioglycosides as potentially active in comparison with doxorubicin against MCF-7 cancer.