Abstract
Treatment of the appropriate sulfonamide diazonium chlorides 2a-f with phenacyl thiocyanate 3 in methanol containing pyridine afforded the 2-imino-1,3,4-thiadiazols 5 a-f through the intermediates 4a-f. The cytotoxic activity of the synthesized compounds against a liver (HepG2), colon (HCT-116), breast (MCF-7), and prostate (PC3) human cancer cell lines was evaluated. The results revealed that the tested compounds displayed moderate to weak cytotoxic activity.