Abstract
The quinolinone structure is an attractive scaffold for drug discovery research. Quinolinones are valuable as therapeutic agents for various diseases. A series of novel 1-substituted 8-methoxy-2-oxo-1H-quinoline-3-carboxylic acid derivatives have been synthesized via the addition of ethyl 3-aryl-2-cyanoacrylates to 8-methoxy-2-oxo-1H-quinoline-3-carboxylic acid and 5-bromo-8-methoxy-2-oxo-1H-quinoline-3-carboxylic acid. The subsequent condensation with hydrazine hydrate afforded the corresponding 5-aminodihydropyrazol-3-one derivatives bearing a quinolinone moiety. The structure of the synthesized compounds was confirmed by spectroscopic methods and elemental analyses. Some 1-substituted 8-methoxy-2-oxo-1H-quinoline-3-carbox-ylic acid derivatives were evaluated in vitro against MCF-7 breast cancer cell line.