Abstract
The cytotoxicity and antibacterial activity of Tetrakis-[(4-methoxy)-phthalocyaninato]Zn(II) were assayed by micro-dilution bioassay and the disc diffusion method against bacterial and fungal strains. All bacterial strains were particularly sensitive to the ZnPc with low MICs values ranging from 1 to 2 mg/mL and less active against the four Candida species tested with a diameter of growth inhibition about 6 mm and a MICs values ranging from 1 to 4 mg/mL. The cytotoxicity of our compound was evaluated on HEp-2 cells using the MTT salt reduction assay. The tested compound has no toxicity on HEp-2 cells (CC50 > 1000 mu g. mL(-1)) and appears to be a promising antimicrobial agent.