Abstract
Diazocoupling reaction of curcumin with different diazonium salts of
-toluidine, 2-aminopyridine, and 4-aminoantipyrine in pyridine yielded the arylhydrazones
-
. Arylhydrazone of
-toluidine reacted with urea, thiourea, and guanidine nitrate to produce 5,6-dihydropyrimidines. Further reaction of
with 2,3-diaminopyrdine in sodium ethoxide solution yielded 1
-pyrido[2,3-
][1,4]diazepine derivative.
(2,5-dihydroisoxazole) is obtained from the reaction of
with hydroxylamine hydrochloride, while its reactions with hydrazines afforded the respective 4,5-dihydro-1
-pyrazoles. The target compounds were evaluated as antioxidant and antibacterial agents. The tested compounds showed good to moderate activities compared to ascorbic acid and chloramphenicol, respectively.