Abstract
We synthesized some newer thiazole analogs and screened them for antibacterial action against some selected bacterial strains by using cup plate method. In the present work, we synthesized 4-amino-N-(4-phenylthi-azol-2-yl)benzene sulfonamide derivatives (2a-f) by refluxing substituted 4-phenyl thiazol-2-amine derivatives with 4-aminobenzene-1-sulfonyl chloride in presence of pyridine and acetic anhydride. The structures of title compounds were confirmed by Infrared, Proton nuclear magnetic resonance, Mass spectral, and elemental analysis. The antibacterial and antifungal activities of title compounds (2a-f) reported that compounds, 2d, 2e, and 2f are showing good activity against Staphylococcus aureus at 300 mu g/mL, and compound 2b has good activity against Bacillus subtilis. Whereas compounds 2c, 2e, and 2f have shown good activity against Escherichia coli. Compound 2d was showing good activity against Klebsiella pneumoniae at 300 mu g/mL.