Abstract
In an attempt to develop new tumor imaging radiotracers with favorable biochemical properties, we have synthesized new
68
Ga-2-acetylpyridine semicarbazone (
68
Ga-[APSC]
2
) as a potential positron emission tomography (PET) tumor imaging agent using a straightforward and a one-step simple reaction. Radiochemical yield and purity were quantitative without HPLC purification. Biodistribution studies in nude mice model bearing human MDA-MB-231 cell line xenografts displayed significant tumor uptake of
68
Ga-[APSC]
2
radiotracer after 2 h postinjection (p.i.). The initial results demonstrate that
68
Ga-[APSC]
2
radiotracer may be useful probe for detecting and staging of hypoxic tumor using PET imaging modality.