Abstract
2-Oxo-2
H
-chromene-3-carbohydrazide derivatives
2a
,
b
react with 2-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}-3-oxo-butyric acid ethyl esters
4a
–
c
to give 3-methyl-1-[(2-oxo-2
H
-chromen-3-yl) carbonyl]-4-{[4-(substituted thiazol-2-yl)iminoethyl)-phenyl]hydrazono}]-2-pyrazolin-5-one derivatives
5a
–
f
. A considerable increase in the reaction rate had been observed with better yield using microwave irradiation for the synthesis of compounds
2a
,
b
,
3a
–
c
, and
5a
–
f
. The synthesized products were tested against
B. subtilis
,
S. aureus
, and
E. coli
as well as
C. albicans
compared with tetracycline and nystatin as reference drugs.