Abstract
Perimidines are peri-naphtho-fused derivatives of pyrimidine. They are of particular
interest as they are a rare example of an azine in which the lone pair of electrons of
pyrrole-like nitrogen participates in the π-system of the molecule. Perimidine is an interesting
class of heterocyclic compounds. Various synthetic analogs of perimidines have been
prepared and evaluated for many pharmacological activities in different models with desired
findings. They exhibit biological activities as antitumor, antiulcer, antimicrobial, and antifungal
agents. This review is an attempt to organize the synthesis and chemical reactions of
perimidine analogs reported to date systematically since 1955. It should be noted that this
review is the first one that includes the preparation and reactions of the perimidine ring.