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Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines
Journal article   Peer reviewed

Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines

Molecules (Basel, Switzerland), Vol.15(10), pp.7016-7034
01/10/2010
PMCID: PMC6259257

Abstract

Biochemistry & Molecular Biology Chemistry Chemistry, Multidisciplinary Life Sciences & Biomedicine Physical Sciences Science & Technology
This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed by treatment with multifunctional nucleophiles provided access to a variety of derivatives.

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