Abstract
A new series of hydrazone, 2H-benzopyranone-3-carboxamide and 2H-benzopyranone-3-carbonylthiosemicarbazide derivatives were synthesized from the alkyl 7-hydroxy-2H-benzopyranone-3-carboxylate (1a,b) and dibromo derivatives (6a,b) as a key starting materials. The structures of the synthesized new compounds were confirmed by IR, H-1, C-13-NMR, MS, and elemental analysis. Some hydrazone derivatives and N-substituted 2H-benzopyranone-3-carboxamides were evaluated for their anticancer activity against HepG-2 cell lines. Some of these compounds shared good cytotoxicity.