Abstract
During the last three decades the extent of life-threatening fungal infections has increased remarkably worldwide. Synthesis and structure elucidation of certain imidazole-semicarbazone conjugates 5a-o are reported. Single crystal X-ray analysis of compound 5e unequivocally confirmed its assigned chemical structure and the (E)-configuration of its imine double bond. Compound 5e crystallized in the triclinic system, P-1, a = 6.3561 (3) angstrom, b = 12.5095 (8) angstrom, c = 14.5411 (9) angstrom, = 67.073 (4)degrees, = 79.989 (4)degrees, =84.370 (4)degrees, V = 1048.05 (11) angstrom(3), Z = 2. In addition, DIZ and MIC assays were used to examine the in vitro antifungal activity of the title conjugates 5a-o against four fungal strains. Compound 5e, bearing a 4-ethoxyphenyl fragment, showed the best MIC value (0.304 mu mol/mL) against both C. tropicalis and C. parapsilosis species, while compounds 5c (MIC = 0.311 mu mol/mL), 5k, and 5l (MIC = 0.287 mu mol/mL) exhibited the best anti-C. albicans activity.