Abstract
The synthesis of certain quinoline-3-carboxylic acid derivatives structurally related to flufenamic acid was achieved. Most compounds possessed moderate anti-inflammatory activity as compared with flufenamic acid. 4-Hydroxy-7-trifluoromethyl-quinoline-3-carbolxylic acid was found to be the most potent and least toxic (LD sub(50) = 800 mg/kg) when compared with flufenamic acid (LD sub(50) = 510 mg/kg). The structure-activity relationship is discussed.