Sign in
Back
Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines
Journal article   Peer reviewed

Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines

Osama M Ahmed, Mahmoud A Mohamed, Rasha R Ahmed and Sayed A Ahmed
European journal of medicinal chemistry, Vol.44(9), pp.3519-3523
01/09/2009
DOI: https://doi.org/10.1016/j.ejmech.2009.03.042
PMID: 19398146

Abstract

Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Survival - drug effects Drug Screening Assays, Antitumor Humans Molecular Structure Pyrazoles - chemical synthesis Pyrazoles - chemistry Pyrazoles - pharmacology Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Pyrimidines - chemical synthesis Pyrimidines - chemistry Pyrimidines - pharmacology Structure-Activity Relationship
Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with sodium salt of 3-hydroxy-1-(2-naphthyl)prop-2-en-1-one gives pyridin-2-one, pyridin-2(1H)-thione, and pyrazolo[1,5-a]pyrimidine derivatives. These derivatives showed potent anti-tumor cytotoxic activity in vitro using different human cancer cell lines.

Metrics

1 Record Views

Details