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Synthesis and antibacterial testing of some new quinolines, pyridazinoquinolines and spiroindoloquinolines
Journal article

Synthesis and antibacterial testing of some new quinolines, pyridazinoquinolines and spiroindoloquinolines

A A el-Ahl, M M Mashaly and M A Metwally
Bollettino chimico farmaceutico, Vol.135(5), pp.297-300
05/1996
PMID: 8942057

Abstract

4-Quinolones Anti-Infective Agents - chemical synthesis Anti-Infective Agents - pharmacology Escherichia coli - drug effects Indoles - chemical synthesis Indoles - pharmacology Microbial Sensitivity Tests Pyridazines - chemical synthesis Pyridazines - pharmacology Quinolines - chemical synthesis Quinolines - pharmacology
3-Dicyanomethylideneindole derivatives were involved in (i) ring expansion reactions in alcoholic piperidine to form new quinolines from which a new pyridazinoquinoline was synthesised; and (ii) formation of new spiroindoloquinolines by reactions with cyclohexanone and beta-tetralone. The suggested structures of the new products were confirmed by IR, 1H-NMR, 13C-NMR and mass spectral analyses. Some of the new derivatives were active against the bacteria Escherichia cell.

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