Abstract
[Display omitted]
A series of imidazolinone and benzoxazole derivatives (3 and 5) have been synthesized by the condensation of oxazolinone derivatives (2a–c) with aniline and 2-hydroxyaniline. Acetyl derivatives (4, 6 and 7) were prepared via acetylation of compounds 3 and 5 with acetic anhydride and chloroacetyl chloride. The results revealed that imidazolinone and benzoxazole derivatives are potent against the cancer cell lines MCF-7 and HePG2. In particular, benzoxazole derivatives are more potent than imidazolinone derivatives.