Abstract
A New series of 3-benzyl-4-oxo-6-iodo-3H-quinazoline derivatives was synthesized and evaluated for their anticonvulsant activity adopting various screening models. Compound 2c (ED50 73.1 mg/kg) showed a 100% protection against PTZ-induced clonic convulsions with a wide safety margin compared to valproate (ED50 102 mg/kg). Also, compounds 4a, 6a, 9b and 10a showed 83.3% protection. Meanwhile, compounds 2c, 4a and 10a proved to be GABA-mimetic agents.