Abstract
Various 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea (5a–p) were designed keeping in view the structural requirements suggested in the pharmacophore model for anticonvulsant activity. Their in vivo anticonvulsant screenings were performed by two most adopted seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). Compound 5f was found active in MES screening while compounds 5h, 5i, 5k and 5l showed significant anticonvulsant activity in both the screenings and were devoid of any neurotoxicity. Compound 5h and 5i showed marked protection at 300mg/kg against MES and scPTZ screening. Compound 5i also showed protection against MES screening at the dose of 100mg/kg. In 6Hz screening these two compounds showed significant protection and emerged as lead compounds for future investigations.
[Display omitted] Various 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea (5a–p) were synthesized and evaluated. Anticonvulsant screening revealed some potential compounds that were active in both MES and scPTZ screenings.
► Various 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea (5a–p) were synthesized and evaluated. ► Compound 5f was found active in MES screening while compounds 5h, 5i, 5k and 5l showed significant anticonvulsant activity in both the screenings and were devoid of any neurotoxicity. ► Compound 5h and 5i showed marked protection at 300mg/kg against MES and scPTZ screening. ► In 6Hz screening compounds 5h and 5i showed significant protection.