Synthesis and antifungal activity of novel pyrano[2′,3′:4,5]thiazolo[2,3- b]quinazolines, pyrido[2′,3′:4,5]thiazolo[2,3- b]quinazolines and pyrazolo[2′,3′:4,5]thiazolo[2,3- b]quinazolines

Soad M Abdel-Gawad; Mohamed S.A El-Gaby; Moustafa M Ghorab; Mostafa M. Ghorab

doi:10.1016/S0014-827X(00)00042-2

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Synthesis and antifungal activity of novel pyrano[2′,3′:4,5]thiazolo[2,3- b]quinazolines, pyrido[2′,3′:4,5]thiazolo[2,3- b]quinazolines and pyrazolo[2′,3′:4,5]thiazolo[2,3- b]quinazolines

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Synthesis and antifungal activity of novel pyrano[2′,3′:4,5]thiazolo[2,3- b]quinazolines, pyrido[2′,3′:4,5]thiazolo[2,3- b]quinazolines and pyrazolo[2′,3′:4,5]thiazolo[2,3- b]quinazolines

Soad M Abdel-Gawad, Mohamed S.A El-Gaby, Moustafa M Ghorab and Mostafa M. Ghorab

Farmaco (Società chimica italiana : 1989), Vol.55(4), pp.287-292

01/04/2000

DOI: https://doi.org/10.1016/S0014-827X(00)00042-2

PMID: 10966160

Abstract

Antifungal activity

Pyranothiazoloquinazoline

Thiazoloquinazolines

The starting materials thiazolo[2,3- b]quinazolines ( 5a, b) were obtained in one pot synthesis by treating octahydroquinazoline ( 2) with chloroacetic acid and aromatic aldehydes. Thiazoloquinazoline ( 5) was reacted with CH 2(CN) 2/piperidine and CH 2(CN) 2/NaOH (CH 3OH), to furnish pyrano[2′,3′:4,5]thiazolo[2,3- b]quinazolines ( 6a, b) and pyrido[2′,3′:4,5]thiazolo[2,3- b]quinazoline ( 7), respectively. Refluxing of 5a with NH 2CSNH 2/KOH and hydrazines in ethanol furnished the corresponding, [1,3]thiazino[4′5′:4,5]thiazolo[2,3- b]quinazoline ( 10) and pyrazolo[3′,4′:4,5]thiazolo[2,3- b]quinazolines ( 11a, b), respectively. Antifungal activity was shown for some of the synthesized compounds.

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Title: Synthesis and antifungal activity of novel pyrano[2′,3′:4,5]thiazolo[2,3- b]quinazolines, pyrido[2′,3′:4,5]thiazolo[2,3- b]quinazolines and pyrazolo[2′,3′:4,5]thiazolo[2,3- b]quinazolines
Creators - without role: Soad M Abdel-Gawad - Al Azhar University
Mohamed S.A El-Gaby - Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut 71524, Egypt
Moustafa M Ghorab - Department of Drug Radiation Research, National Centre for Radiation Research and Technology, PO Box 29, Nasr City, Cairo, Egypt
Mostafa M. Ghorab - King Saud University
Publication Details: Farmaco (Società chimica italiana : 1989), Vol.55(4), pp.287-292
Publisher: Elsevier SAS
Identifiers: 9952981008331
Academic Unit: King Saud University
Language: English
Resource Type: Journal article