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Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives
Journal article   Peer reviewed

Synthesis and antihepatotoxic activity of 2-(substituted-phenyl)-5-(2,3-dihydro-1,4-benzodioxane-2-yl)-1,3,4-oxadiazole derivatives

Bahar Ahmed, Habibullah, Shamshir Khan and Habibullah Khalilullah
Journal of enzyme inhibition and medicinal chemistry, Vol.26(2), pp.216-221
04/2011
DOI: https://doi.org/10.3109/14756366.2010.489899
PMID: 20593971

Abstract

Animals Carbon Tetrachloride - chemistry Carbon Tetrachloride Poisoning Chemical and Drug Induced Liver Injury Dioxanes - chemical synthesis Dioxanes - chemistry Dioxanes - pharmacology Liver - drug effects Molecular Structure Oxadiazoles - chemical synthesis Oxadiazoles - chemistry Oxadiazoles - pharmacology Rats Silymarin - pharmacology
Novel 1,3,4-oxadizole derivatives containing the 1,4-dioxane ring system were synthesised starting from 2,3-dihydro-1,4-benzodioxane-2-carbohydrazide. The synthesised compounds were evaluated for antihepatotoxic activity against CCl₄-induced hepatotoxicity in rats. Some compounds demonstrated a significant antihepatotoxic activity comparable to the standard drug Silymarin.

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