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Synthesis and antiinflammatory activity of some new 2-(4-isobutylphenyl) propionic acid derivatives
Journal article   Peer reviewed

Synthesis and antiinflammatory activity of some new 2-(4-isobutylphenyl) propionic acid derivatives

M Amir and S Shahani
Indian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry, Vol.37(5), pp.502-505
01/05/1998

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A number of oxadiazole, thiadiazole and triazole derivatives of 2-(4-isobutylphenyl)propionic acid have been synthesized and evaluated for their antiinflammatory activity. The tested compounds shaw 77.2 to 48. 05% inhibition at 100 mg/kg dose compared to ibuprofen which shows 61.04% inhibition at 100 mg/kg dose in carrageenin induced paw edema in rats.

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