Abstract
A series of new 5-chloro-3-substituted-1,2,4-triazolo[4,3-c]quinazolines and 5-chloro-2-substituted 1,2,4-triazolo[1,5-c]quinazolines was prepared via several synthetic routes. Most of the compounds were prepared by cyclization of 2,4-dichloroquinazoline with thiosemicarbazide or acid hydrazides; other compounds were obtained from (2-chloro-4-quinazolyl)hydrazine by reaction with carboxylic acids or acid chlorides. The synthesized compounds were evaluated as antiinflammatory agents through the carrageenin-induced paw edema test. The screening data revealed that four of the tested compounds have activity ranging from more potent to equipotent to ketoprofen. Moreover, compound 16, that was found to possess pronounced antiinflammatory activity, was tested for its analgesic activity and ulcerogenic effect as well.