Abstract
This work aimed to synthesis some new different heterocyclic compounds based on phenylpyrazole-4-carbaldehyde derivative (1) reacted with cyanoacetohydrazide to afford N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene]-2-cyanoacetohydrazide (2). It was cyclized by acetyl acetone, and aromatic aldehyde, respectively, to give pyrazolo-pyridone (4) and substituted pyrazolochromene (6 and 8), respectively. Pyrazolo triazole (10) was obtained by coupling of 1-azido-4-fluorobenzene with (2), which was diazotized by 3-(chlorodiazenyl)-4,6-dimethyl-1H-pyrazolo[3,4-b]pyridine to give pyrazolo pyridine derivative (11). N,N-Dimethylformamide dimethyl acetal reacted with (2) to afford [(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene]-2-cyano-3-(dimethylamino)-acrylohydrazide (13). The compound before compound yield substituted pyrazole-4-carbohydrazide (15). Also, compound (2) reacted with phNCS in the presence of KOH and furnish compound (22), which preferred over compound (20) All synthesized compounds were established using IR, H-1-NMR. All synthesized compounds were screened for their antimicrobial activities.