Abstract
Alkylation of 2-thioxo-5,6,7,8-tetrahydrobenzothieno[2,3-d] pyrimidin-4(3)-one (2) gave the -alkylating products 3-5. Reaction of 3-carboxamide 1 with terphthaloyl, isophthaloyl chloride and benzoin afforded bisthienopyrimidines 6, 7 and pyrrolopyrimidineone 9, respectively. Condensation of 1 with aromatic aldehydes afforded compounds 11a-c. Alkylation of compounds 11a-c with allyl bromide resulted in -alkyl thienopyrimidine derivatives 12a-c. Alkylation of 11a,b with 4-bromobutyl acetate gave butylacetate derivatives 13a,b. which were deacetylated to provide 14a,b. All the newly synthesized compounds were characterized by the IR, H-1, C-13 NMR and elemental analyses. Selected members of these compounds were screened for antimicrobial activity.