Abstract
A series of novel tetrabromo-bis(substituted benzyl)cycloalkanones have been synthesized through a rapid, simple, and efficient methodology in an excellent isolated yield and characterized via IR, NMR (H-1-, C-13-NMR, DEPT 135, DEPT 90) and mass spectrometry. All compounds were assayed for their in vitro antimicrobial activities against eight bacteria and five fungi. They showed stronger antibacterial than antifungal activities. Compounds 4c, 4d and 41, containing a methoxy or chloro substituent on the para or meta position of the phenyl ring, showed comparable minimum inhibitory concentration (MIC) values to those of the standard antibiotics streptomycin and tetracycline. Among all the tested compounds, 4i exhibited good to moderate antifungal activity against all the tested fungal strains used.