Abstract
Condensation of 6-chloro-2-hydrazinoquinoline (1) with monosaccharides 2a-e gave the corresponding sugar hydrazones 3a-e which upon acetylation gave the corresponding acetates 4f-j. Cyclization of 3a-e using iron (III) chloride afforded the acyclic nucleosides of triazoloquinolines 5a-e which were also acetylated to give 6f-j. Compound I was also condensed with aldehydes and isatin to give the corresponding hydrazones 7-10. Reactions of I with ethylchloroformate, phthalic anhydride, acetyl acetone and tosyl chloride were also investigated. All compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria.