Abstract
A new series of quinazolinone derivatives were synthesized starting with anthranilic acid and cinnamoylisothiocyanate in high yields 55-99%. Their structures were elucidated by H-1/C-13 NMR, FTIR spectroscopy, MS and elemental analysis. The study of the biological activity of all the novel compounds is reported. The minimal inhibitory concentration of some quinazolin-5-one derivatives showed potential activity against both Gram (+ve) and Gram (-ve) microorganisms more than the reference cefotaxime. In addition, some derivatives of quinazolin-5-one can be considered as antifungal agents comparing with the standard drug nystatin.