Abstract
A large variety of 2-substituted benzimidazoles have been found to possess anti-inflammatory, antispasmodic, antihistaminic, antimicrobial, anticancer, cycloxygenase inhibitor, and HIV-1 reverse transcriptase inhibitor activities. 2-Alkyl benzimidazole and 2-aryl benzimidazoles were synthesized with different acids namely acetic acid, o-chlorobenzoic acid, benzoic acid and cinnamic acid. These were further treated with tosyl chloride and benzoyl chloride to get N-substituted benzimidazole derivatives. These N-substituted benzimidazoles were tested for antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Some of the products exhibited interesting activity with known standard drug at same concentration.