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Synthesis and antimicrobial studies of some novel bis-[1,3,4]thiadiazole and bis-thiazole pendant to thieno[2,3-b]thiophene moiety
Journal article   Open access  Peer reviewed

Synthesis and antimicrobial studies of some novel bis-[1,3,4]thiadiazole and bis-thiazole pendant to thieno[2,3-b]thiophene moiety

Nabila Abdelshafy Kheder and Yahia Nasser Mabkhot
International journal of molecular sciences, Vol.13(3), pp.3661-3670
01/03/2012
DOI: https://doi.org/10.3390/ijms13033661
PMCID: PMC3317734
PMID: 22489174

Abstract

Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Aspergillus fumigatus - drug effects Bacillus subtilis - drug effects Candida albicans - drug effects Clotrimazole - pharmacology Drug Design Escherichia coli - drug effects Geotrichum - drug effects Itraconazole - pharmacology Microbial Sensitivity Tests Penicillin G - pharmacology Pseudomonas aeruginosa - drug effects Staphylococcus aureus - drug effects Streptomycin - pharmacology Thiadiazoles - chemical synthesis Thiadiazoles - chemistry Thiadiazoles - pharmacology Thiophenes - chemical synthesis Thiophenes - chemistry Thiophenes - pharmacology
The synthetic utility of 3,3'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis (3-oxopropanenitrile) (1) in the synthesis of some novel bis-[1,3,4-thiadiazole] 6a-g and bis-thiazole 10 and 13 derivatives with thieno[2,3-b]thiophene moiety is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.
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https://doi.org/10.3390/ijms13033661View
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