Abstract
In the present investigation, a series of 3a,4-dihydro-3H-indeno [1,2-c] pyrazole-2-carboxamide analogues were synthesized and were evaluated for antitubercular activity by two fold serial dilution technique. All the newly synthesized compounds showed low to good inhibitory activities against Mycobacterium tuberculosis H37Rv and multi-drug resistant M. tuberculosis (MDR-TB). 3-(4-fluorophenyl)-N-(4-chlorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno [1,2-c] pyrazole-2-carboxamide (4c) was found to be the most promising compound active against M. tuberculosis, H37Rv and MDR-TB with minimum inhibitory concentrations 0.83 μM and 3.32 μM respectively.
Eighteen novel 3a,4-dihydro-3H-indeno [1,2-c] pyrazole-2-carboxamide analogues were synthesized. The compound 4c was found to be active at 0.83 μM and 3.32 μM against MTB and MDR-TB respectively. [Display omitted]
▸ A series of 18 3a,4-dihydro-3H-indeno [1,2-c] pyrazole-2-carboxamides were synthesized. ▸ Compound 4c was found to be the most promising compound active against MTB and MDR-TB. ▸ When compared with INH the compound, 4c was 13.6 folds more active against MDR-TB.