Abstract
A series of 2-methylthio-pyrido-triazolopyrimidines (
) were prepared by the reaction of dimethyl-
-cyanoimidodithiocarbonate with hydrazinopyridine carboxylic acid as starting reactants. Their chemical structures were affirmed with HREI-MS, IR and NMR analyses. The target compounds (
) were evaluated for their antioxidant activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some pyrido-triazolopyrimidines showed good activity as antioxidant agents, in particular, compounds
and
were found to possess good antioxidant activity. Butylated hydroxyl toluene (BHT) was used as reference drug.