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Synthesis, and antitubercular and antimicrobial activity of 1 '-(4-chlorophenyl)pyrazole containing 3,5-disubstituted pyrazoline derivatives
Journal article   Peer reviewed

Synthesis, and antitubercular and antimicrobial activity of 1 '-(4-chlorophenyl)pyrazole containing 3,5-disubstituted pyrazoline derivatives

N. Harikrishna, Arun M. Isloor, K. Ananda, Abdulrahman Obaid and Hoong-Kun Fun
New journal of chemistry, Vol.40(1), pp.73-76
01/01/2016
DOI: https://doi.org/10.1039/c5nj02237a

Abstract

Chemistry Chemistry, Multidisciplinary Physical Sciences Science & Technology
A new series of 1'-(4-chlorophenyl)-5-(substituted aryl)-3'-(substituted aryl)-3,4-dihydro-2H, 1'H-[3,4']bipyrazolyl derivatives (6a-e, 8a-e, 10a-e) have been synthesized, characterized and screened for antimicrobial and antitubercular activity. Among the synthesized compounds, the minimum inhibition concentration of 10e was found to be as low as 1.56 mu g ml(-1) and that of 10c was 6.25 mu g ml(-1) as compared to the standard anti-tb drugs pyrazinamide and streptomycin.

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