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Synthesis and behaviour of 2-(furan-2-yl)vinyl-4H-3,1-benzoxazin-4-one towards nitrogen and carbon nucleophiles
Journal article   Peer reviewed

Synthesis and behaviour of 2-(furan-2-yl)vinyl-4H-3,1-benzoxazin-4-one towards nitrogen and carbon nucleophiles

Yaser A. El-Badry, Naglaa M. Anter and Mahr A. El-Hashash
Indian journal of chemistry. Sect. B. Organic chemistry, including medicinal chemistry, Vol.53(12), pp.1574-1583
01/12/2014

Abstract

Chemistry Chemistry, Organic Physical Sciences Science & Technology
A convenient new procedure for the synthesis of 2-(furan-2-yl)vinyl-4H-3,1-benzoxazin-4-one 4 is reported. Reaction of the respective benzoxazinone with various nitrogen nucleophiles affords 3-substituted quinazolinone and benzamide derivatives. Benzoxazinone 4 is converted to 4(3H)-quinazolinone followed by acylation, chlorination, and alkylation, which also is catalytically hydrogenated.

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