Abstract
Some pyrimidine derivatives were synthesized by reacting corresponding chalcones with guanidine carbonate followed by condensing the active hydrogen atom of 2-amino group of 2-amino-4-(substitutedphenyl)-6-(substitutedphenyl) pyrimidines with formaldehyde and morpholine to give 2-morpholinomethylamino-4-(substitutedphenyl)-6-(substitutedphenyl) pyrimidines (3). Their IR, H-1 NMR and elemental analysis were in accord with assigned structures. The antimicrobial screening of these compounds revealed that, in most of the compounds, introduction of morpholinomethyl group at C 2-amino group of pyrimidine nucleus resulted in increased antimicrobial activity against S. aureus and E coli but no appreciable increase in antimicrobial activity was noted against S. typhi and C. albicans. All Mannich bases exhibited mild anticonvulsant activity as compared to phenytoin.